Abstract
We show that light-assisted oxidation with hydrogen peroxide effectively and rapidly opens holes in carbon nanohorn walls and, more importantly, creates abundant oxygenated groups such as carboxylic groups at the hole edges. These oxygenated groups reacted with the protein bovine serum albumin. The obtained conjugates were highly dispersed in phosphate-buffered saline and were taken up by cultured mammalian cells via an endocytosis pathway.
MeSH terms
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Amides / chemistry
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Animals
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Biocompatible Materials / chemistry*
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Biocompatible Materials / metabolism
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Carbon / chemistry*
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Carbon / metabolism
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Carboxylic Acids / chemistry
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Cattle
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Cell Line, Tumor
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Endocytosis
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Humans
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Hydrogen Peroxide / chemistry
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Imides / chemistry
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Light*
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Nanostructures / chemistry*
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Oxidation-Reduction / radiation effects
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Oxygen / chemistry*
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Proteins / chemistry*
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Serum Albumin, Bovine / chemistry
Substances
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Amides
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Biocompatible Materials
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Carboxylic Acids
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Imides
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Proteins
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Serum Albumin, Bovine
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Carbon
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Hydrogen Peroxide
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Oxygen