Venous thrombo-embolism in India

Eur J Vasc Endovasc Surg. 2009 Apr;37(4):482-5. doi: 10.1016/j.ejvs.2008.11.031. Epub 2009 Feb 8.

Abstract

Introduction: Venous thrombo-embolism (VTE) has traditionally been considered rare in Asia. Recent reports from Hong Kong and Singapore indicate an increasing incidence of VTE.

Objectives: To determine the incidence of VTE among hospitalised patients and study the predisposing factors and hence to increase the awareness of the need for VTE prophylaxis.

Methods: This is a retrospective study carried out on all patients diagnosed with VTE between 1996 and 2005 at our hospital. In-patient records were used to collect data while out-patient records were used for follow-up outcomes.

Results: The incidence of VTE was 17.46 per 10,000 admissions. Malignancy (31%) was the most common predisposing factor, followed by postoperative status (30%). The incidence following surgery was five per 10,000 operations. General surgery patients had the highest incidence of deep vein thrombosis (DVT; 40.3%), while the incidence in orthopaedic patients was 20.1%. Low-molecular-weight heparin (LMWH) has been increasingly used therapeutically over the years. Pulmonary embolism was diagnosed in 14.9% of the study patients. Mortality in those with confirmed pulmonary embolism was 13.5%.

Conclusion: VTE is no longer a rarity in India. General surgical operations are the most common causes of postoperative DVT. Pulmonary embolism continues to be 'suspected' more often than it is diagnosed.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Anticoagulants / therapeutic use
  • Child
  • Child, Preschool
  • Drug Utilization
  • Female
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Hospitals, Teaching
  • Humans
  • Incidence
  • India / epidemiology
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Neoplasms / epidemiology
  • Postoperative Complications / epidemiology
  • Pulmonary Embolism / diagnosis
  • Pulmonary Embolism / epidemiology
  • Retrospective Studies
  • Sex Distribution
  • Specialties, Surgical
  • Thrombolytic Therapy / statistics & numerical data
  • Vena Cava Filters / statistics & numerical data
  • Venous Thromboembolism / epidemiology*
  • Venous Thromboembolism / etiology
  • Young Adult

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight