Noonan syndrome associated with systemic lupus erythematosus

M P Lisbona; M Moreno; C Orellana; J Gratacos; M Larrosa

doi:10.1177/0961203308094996

Noonan syndrome associated with systemic lupus erythematosus

Lupus. 2009 Mar;18(3):267-9. doi: 10.1177/0961203308094996.

Authors

M P Lisbona¹, M Moreno, C Orellana, J Gratacos, M Larrosa

Affiliation

¹ Unitat de Reumatologia, Hospital de Sabadell, Institut Universitari Parc Taulí (UAB), Sabadell (Barcelona), Spain.

PMID: 19213867
DOI: 10.1177/0961203308094996

Abstract

Noonan syndrome (NS) is a developmental disorder characterised mainly by cardiac defects and craniofacial dysmorphia. An association between NS and some autoimmune diseases, such as thyroiditis and systemic lupus erythematosus (SLE), has been suggested. We report the case of a 28-year-old man with a diagnosis of NS and autoimmune hypothyroidism who developed symptoms and immunologic features of SLE.

Publication types

Case Reports

MeSH terms

Adolescent
Adult
Comorbidity
Humans
Lupus Erythematosus, Systemic / etiology*
Lupus Erythematosus, Systemic / pathology
Lupus Erythematosus, Systemic / physiopathology
Male
Noonan Syndrome / complications*
Noonan Syndrome / pathology
Noonan Syndrome / physiopathology
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics
Young Adult

Substances

PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11