Abstract
Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC(50) values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Contact Inhibition
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Electrophoresis, Agar Gel
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Gold Colloid / chemistry*
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Gold Colloid / metabolism
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Inhibitory Concentration 50
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L-Selectin / metabolism*
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Leukocytes / metabolism
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Ligands
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P-Selectin / metabolism*
Substances
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Gold Colloid
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Ligands
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P-Selectin
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L-Selectin