Abstract
A novel cycloheptapeptide, tunicyclin A, with a unique tricyclic ring cyclopeptide skeleton, was isolated from Psammosilene tunicoides. Its structure was elucidated by extensive NMR and MS analysis. Biogenetically, tunicyclin A might be derived from cyclo-(Pro(1)-Ser(2)-(gamma-keto-delta-aldehedyl-Glu(3))-Leu(4)-Val(5)-Gly(6)-Ser(7)) via two steps of nucleophilic addition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Caryophyllaceae / chemistry*
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Doxorubicin / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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HL-60 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
Substances
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Antineoplastic Agents
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Drugs, Chinese Herbal
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Peptides, Cyclic
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tunicyclin A
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Doxorubicin