Myomectomy is rarely performed during an ongoing pregnancy because of fear of pregnancy loss and the risk of uncontrolled hemorrhage necessitating hysterectomy. Even now, few cases are performed during pregnancy and most cases have been performed at the time of Cesarean section. A case of successful myomectomy performed in the second trimester for a large subserous fibroid, weighing 3900 g and causing severe pressure symptoms and subacute intestinal obstruction, is described. The pregnancy continued uneventfully until term.