Abstract
The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavior to foster drug-seeking behavior.
Publication types
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Comment
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
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Dopamine / metabolism*
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Humans
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Limbic System / drug effects
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Limbic System / enzymology*
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Limbic System / physiopathology
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Protein Binding / physiology
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Protein Structure, Tertiary / physiology
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Receptors, Dopamine D3 / drug effects
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Receptors, Dopamine D3 / metabolism*
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Substance-Related Disorders / enzymology*
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Substance-Related Disorders / physiopathology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
Substances
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Receptors, Dopamine D3
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Dopamine