Abstract
Radiation recall dermatitis (RRD) is a rare cutaneous reaction occurring within a previously irradiated field, precipitated by certain drugs. We report a case of RRD occurring after pre-sensitization with pegylated liposomal doxorubicin (PLD) in a woman with Stage IV breast cancer. The RRD occurred in one of the patient's four previous radiotherapy fields. We discuss the time/dose factors of radiation exposure and measure the corresponding skin dose. In our case the radiation dose was low and below previously reported thresholds, and illustrates that there is a more complex interaction between the radiotherapy and the trigger agent than has previously been considered.
MeSH terms
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Breast Neoplasms / radiotherapy*
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Carcinoma, Ductal, Breast / drug therapy*
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Carcinoma, Ductal, Breast / pathology
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Carcinoma, Ductal, Breast / radiotherapy*
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Chemotherapy, Adjuvant / adverse effects
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Doxorubicin / adverse effects
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Doxorubicin / analogs & derivatives*
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Female
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Humans
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Staging
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Polyethylene Glycols / adverse effects*
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Radiation Dosage
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Radiodermatitis / etiology*
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Radiodermatitis / pathology
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Radiodermatitis / therapy
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Radiotherapy / adverse effects
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Severity of Illness Index
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Thigh
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Time Factors
Substances
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liposomal doxorubicin
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Polyethylene Glycols
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Doxorubicin