Clinical trial: a randomized trial comparing fluoroscopy guided percutaneous technique vs. endoscopic ultrasound guided technique of coeliac plexus block for treatment of pain in chronic pancreatitis

Aliment Pharmacol Ther. 2009 May 1;29(9):979-84. doi: 10.1111/j.1365-2036.2009.03963.x.

Abstract

Background: Coeliac plexus block (CPB) is a management option for pain control in chronic pancreatitis. CPB is conventionally performed by percutaneous technique with fluoroscopic guidance (PCFG). Endoscopic ultrasound (EUS) is increasingly used for CPB as it offers a better visualization of the plexus. There are limited data comparing the two modalities.

Aim: To compare the pain relief in chronic pancreatitis among patients undergoing CPB either by PCFG technique or by EUS guided technique.

Methods: Chronic pancreatitis patients with abdominal pain requiring daily analgesics for more than 4 weeks were included. Fifty six consecutive patients (41 males, 15 females) participated in the study. EUSG-CPB was performed in 27 and PCFG-CPB in 29 patients. In both the groups, 10 mL of Bupivacaine (0.25%) and 3 mL of Triamcinolone (40 mg) were given on both sides of the coeliac artery through separate punctures.

Results: Pre and post procedure pain scores were obtained using a 0-10 visual analogue scale. Improvement in pain scores was seen in 70% of subjects undergoing EUS-CPB and 30% in Percutaneous- block group (P = 0.044).

Conclusions: EUS-guided coeliac block appears to be better than PCFG-CPB for controlling abdominal pain in patients with chronic pancreatitis.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Abdominal Pain / drug therapy*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents / therapeutic use
  • Autonomic Nerve Block / methods*
  • Bupivacaine / therapeutic use*
  • Celiac Plexus*
  • Endoscopy
  • Female
  • Fluoroscopy
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Pancreatitis, Chronic / drug therapy*
  • Treatment Outcome
  • Triamcinolone / therapeutic use*
  • Young Adult

Substances

  • Anti-Inflammatory Agents
  • Triamcinolone
  • Bupivacaine