Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997

S B F Brown; E A Mallon; J Edwards; F M Campbell; L M McGlynn; B Elsberger; T G Cooke

doi:10.1038/sj.bjc.6604934

Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997

Br J Cancer. 2009 Mar 10;100(5):807-10. doi: 10.1038/sj.bjc.6604934. Epub 2009 Feb 17.

Authors

S B F Brown¹, E A Mallon, J Edwards, F M Campbell, L M McGlynn, B Elsberger, T G Cooke

Affiliation

¹ Department of Surgery, Crosshouse Hospital, Glasgow Royal Infirmary, Scotland, UK. [email protected]

Abstract

Using archived tumours, those from 1984-1986 and 1996-1997 underwent immunohistochemistry for hormone receptors and grade analysis. A significant shift towards more ER-positive and low-grade disease was found; this appears to reflect screening practices, but could still influence survival.

Publication types

Comparative Study
Multicenter Study

MeSH terms

Adult
Aged
Aged, 80 and over
Breast Neoplasms / etiology*
Breast Neoplasms / metabolism*
Breast Neoplasms / mortality
Breast Neoplasms / pathology
Cohort Studies
Female
Humans
Middle Aged
Receptors, Estrogen / metabolism*
Social Class
Survival Analysis
Time Factors

Substances

Receptors, Estrogen