Reaction energies computed with density functional theory correspond with a whole organism effect; modelling the Ames test for mutagenicity

Chem Commun (Camb). 2009 Mar 7:(9):1094-6. doi: 10.1039/b818744d. Epub 2009 Jan 6.

Abstract

A series of reactions of anilines and their metabolites have been treated with density functional theory to investigate if any of the computed energy changes correlate with mutagenicity.

MeSH terms

  • Algorithms
  • Aniline Compounds / chemistry*
  • Aniline Compounds / toxicity
  • Models, Chemical
  • Mutagenicity Tests
  • Mutagens / chemistry*
  • Mutagens / toxicity
  • Thermodynamics

Substances

  • Aniline Compounds
  • Mutagens
  • aniline