A case of late-onset Tourette's disorder successfully treated with aripiprazole: view from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF)

World J Biol Psychiatry. 2009;10(4 Pt 3):977-80. doi: 10.1080/15622970902718147.

Abstract

We reported a case with late-onset Tourette's disorder (TD) in whom motor tics and emotional instability improved with 18 mg/day of aripiprazole treatment. Plasma HVA levels, but not MHPG levels, were altered during the treatment. In contrast, serum BDNF levels remained consistently low during the treatment course. The present case suggests that aripiprazole might ameliorate tics and emotional instability via influencing dopaminergic neurons in late-onset TD.

Publication types

  • Case Reports

MeSH terms

  • Age Factors
  • Antipsychotic Agents / therapeutic use*
  • Aripiprazole
  • Brain / diagnostic imaging
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Catecholamines / blood
  • Catecholamines / metabolism*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Humans
  • Male
  • Piperazines / therapeutic use*
  • Quinolones / therapeutic use*
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Tourette Syndrome / diagnosis
  • Tourette Syndrome / drug therapy*
  • Young Adult

Substances

  • Antipsychotic Agents
  • Brain-Derived Neurotrophic Factor
  • Catecholamines
  • Piperazines
  • Quinolones
  • Aripiprazole