Disturbed cognitive functions after nasal provocation in patients with seasonal allergic rhinitis

Clin Exp Allergy. 2009 Apr;39(4):500-8. doi: 10.1111/j.1365-2222.2009.03200.x. Epub 2009 Feb 16.

Abstract

Background: Allergic rhinitis (AR) reduces quality of life as a result of impaired psychological well-being and perceived impaired cognitive functioning. Few studies have measured cognitive functions objectively and it remains uncertain whether AR leads to an objective reduction in cognitive functions.

Objective: The present study investigated whether AR is associated with a decrement in several aspects of cognitive functioning. Furthermore, the study investigated whether AR patients invest more 'mental effort' in order to achieve the same cognitive performances as healthy controls.

Methods: Twenty five patients with seasonal allergic rhinitis (SAR) and 26 healthy controls, matched for age, education and sex, were tested on a battery of time-demanding and strenuous objective cognitive tests and subjective questionnaires, both before and after nasal provocation (NP). The cognitive functions assessed were sustained attention, short- and long-term memory and speed of information processing. Mental effort was assessed using visual rating scales.

Results: Sustained but not short cognitive performance was impaired in patients after NP. Patients showed an increased effort on short cognitive tests.

Conclusion: SAR patients suffer from cognitive performance decrements that can be compensated by additional mental effort for short tasks only.

MeSH terms

  • Adult
  • Allergens / immunology
  • Cognition
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / etiology*
  • Cognition Disorders / immunology
  • Female
  • Humans
  • Intelligence Tests
  • Male
  • Nasal Provocation Tests
  • Rhinitis, Allergic, Seasonal / complications*
  • Rhinitis, Allergic, Seasonal / immunology
  • Surveys and Questionnaires

Substances

  • Allergens