Dutch orthopedic thromboprophylaxis: a 5-year follow-up survey

Acta Orthop. 2009 Feb;80(1):109-12. doi: 10.1080/17453670902807441.

Abstract

Background and purpose: Previous surveys in the Netherlands have revealed that guidelines regarding orthopedic thromboprophylaxis were not followed and that a wide variation in protocols exists. This survey was performed to assess the current use of thromboprophylactic modalities and to compare it with the results of a previous survey.

Methods: All departments of orthopedic surgery in the Netherlands were sent a follow-up survey on venous thromboprophylaxis, and the data obtained were compared to the results of a survey performed 5 years earlier.

Results: All departments used pharmacological thromboprophylaxis following arthroplasties of the hip and knee. Low-molecular-weight heparin (LMWH) was used most frequently (79%) of the departments, followed by fondaparinux (13%). 5 years earlier, coumarin treatment was the predominant prophylaxis (79%). All departments prescribed pharmacological prophylaxis after femoral and tibial fractures; 78% used LMWH. Prophylaxis was continued for 6 weeks in 85% of cases. LMWH treatment was initiated on the day before surgery in 31% of cases (65% in the previous survey), perioperatively in 55%, and in the evening following surgery in 24%. In general, for daycare surgery and arthroscopies either no prophylaxis was given or a LMWH was given for 1 day. After anterior cruciate ligament reconstruction, 94% of departments prescribed some form of pharmacological prophylaxis.

Interpretation: The use of pharmacological prophylaxis after arthroplasty of the hip and knee and also after fracture surgery around the hip and knee is common practice in the Netherlands. In 5 years, the widely used coumarin derivates have been largely replaced with LMWH.

Publication types

  • Comparative Study

MeSH terms

  • Anterior Cruciate Ligament / surgery
  • Anticoagulants / administration & dosage*
  • Arthroplasty, Replacement, Hip* / adverse effects
  • Arthroplasty, Replacement, Knee* / adverse effects
  • Coumarins / administration & dosage
  • Follow-Up Studies
  • Fondaparinux
  • Fracture Fixation, Internal* / adverse effects
  • Guideline Adherence
  • Heparin, Low-Molecular-Weight / administration & dosage
  • Humans
  • Netherlands
  • Polysaccharides / administration & dosage
  • Practice Patterns, Physicians'
  • Stockings, Compression
  • Surveys and Questionnaires
  • Thrombosis / prevention & control*

Substances

  • Anticoagulants
  • Coumarins
  • Heparin, Low-Molecular-Weight
  • Polysaccharides
  • coumarin
  • Fondaparinux