Abstract
tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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DNA-Binding Proteins / antagonists & inhibitors*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Drug Design
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Endosomal Sorting Complexes Required for Transport / antagonists & inhibitors*
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Endosomal Sorting Complexes Required for Transport / chemistry
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Endosomal Sorting Complexes Required for Transport / metabolism*
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HIV-1 / growth & development*
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HIV-1 / physiology
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / chemistry
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Transcription Factors / metabolism*
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Virus Replication
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gag Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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Anti-HIV Agents
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DNA-Binding Proteins
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Endosomal Sorting Complexes Required for Transport
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Transcription Factors
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Tsg101 protein
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gag Gene Products, Human Immunodeficiency Virus