Effective control and removal of nitrogen oxides (NO(x)) emission from vehicles exhausts under lean-burn condition is one of the most important targets in scientific research of environmental protection. A comprehensive introduction of NO(x) storage and reduction (NSR), the most promising lean-NO(x) control technology, is given including the sum-up of NSR materials, catalytic activity and related reaction mechanisms. Emphasis is put on the novel multifunctional NSR catalysts, derived from hydrotalcite-like compounds, with characteristic of simultaneous NO(x) strorage-decomposition-reduction. Finally, future research directions in the area of lean-NO(x) control based on mixed oxide catalysts derived from hydrotalcite-like materials is also proposed.