Abstract
Phytoecdysteroid glycosides (1-5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7-9), four flavonoids (10-13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6-14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC(50) of 130 microM in conjunction with low intercalation ability.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amaranthaceae / chemistry*
-
Ecdysteroids / chemistry*
-
Ecdysteroids / isolation & purification
-
Ecdysteroids / pharmacology
-
Enzyme Activation / drug effects
-
Esters / chemistry*
-
Esters / isolation & purification
-
Esters / pharmacology
-
Flavonoids / chemistry
-
Flavonoids / isolation & purification
-
Flavonoids / pharmacology
-
Humans
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Phenols / chemistry
-
Phenols / isolation & purification
-
Phenols / pharmacology
-
Topoisomerase I Inhibitors
Substances
-
Ecdysteroids
-
Esters
-
Flavonoids
-
Phenols
-
Topoisomerase I Inhibitors