Abstract
Three new oleanane-type triterpene saponins, albizosides A-C (1-3), were isolated from the stem bark of Albizia chinensis. Their structures were established by 1D and 2D NMR experiments and chemical methods. Compounds 1-3 showed cytotoxic activity against a small panel of human tumor cell lines as well as hemolytic activity against rabbit erythrocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albizzia / chemistry*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Erythrocytes / drug effects
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Hemolysis / drug effects
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification*
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Oleanolic Acid / pharmacology*
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Rabbits
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Saponins
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albizoside A
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albizoside B
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albizoside C
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Oleanolic Acid