Palladium-catalyzed domino carbopalladation/5-exo-allylic amination of alpha-amino allenamides: an efficient entry to enantiopure imidazolidinones

Org Lett. 2009 Apr 2;11(7):1563-6. doi: 10.1021/ol900171g.

Abstract

Allenamides of alpha-amino acids were converted into enantiopure 2-vinylimidazolidin-4-ones by a carbopalladation/exo-cyclization process. The products were obtained in 2.5:1-5.5:1 dr, with 94-99% ee. The palladium-catalyzed carbonylative cyclization of the same substrates afforded enone structures. Starting from properly substituted allenamides, an intramolecular carbopalladation followed by intramolecular amination gave rise to tricyclic fused-ring imidazolidinones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allyl Compounds / chemistry*
  • Amination
  • Catalysis
  • Cyclization
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Allyl Compounds
  • Imidazoles
  • Palladium