Abstract
Triterpenoids gilvsins A-D (1-4), with oxygenated lanostane skeletons, were isolated from the fruiting body of Phellinus gilvus, together with two known compounds, 24-methylenelanost-8-ene-3beta, 22-diol and 5alpha-ergosta-7,22-diene-3-one. The structures of 1-4 were deduced from analysis of spectroscopic data. The absolute configuration at C-22 of 1 was determined by the modified Mosher's method and the structure of 1 was confirmed by X-ray analysis. The hypoglycemic activities of the crude extract of P. gilvus and the isolated compounds were also evaluated, but were not promising for further investigation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Basidiomycota / chemistry*
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Cell Line
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Complex Mixtures / chemistry
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Complex Mixtures / isolation & purification
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Complex Mixtures / pharmacology
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Gene Expression / drug effects
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Hypoglycemic Agents / chemistry*
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology
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Models, Molecular
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Nuclear Magnetic Resonance, Biomolecular
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Phosphoenolpyruvate Carboxykinase (GTP) / genetics
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Rats
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Complex Mixtures
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Hypoglycemic Agents
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Triterpenes
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Phosphoenolpyruvate Carboxykinase (GTP)