Abstract
We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / pharmacology
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Drug Synergism
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Drug Therapy, Combination
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Fatty Acids, Monounsaturated / administration & dosage
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Fatty Acids, Monounsaturated / pharmacology
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Fluvastatin
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Ibuprofen / administration & dosage
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Ibuprofen / pharmacology
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Indoles / administration & dosage
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Indoles / pharmacology
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Metronidazole / administration & dosage
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Metronidazole / pharmacology
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Microbial Sensitivity Tests
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Naphthalenes / administration & dosage
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Naphthalenes / pharmacology*
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Pythium / drug effects*
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Rifampin / administration & dosage
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Rifampin / pharmacology
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Terbinafine
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Fatty Acids, Monounsaturated
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Indoles
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Naphthalenes
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Metronidazole
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Fluvastatin
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Amphotericin B
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Terbinafine
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Rifampin
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Ibuprofen