Abstract
Amino acids are key nutrients for protein synthesis and many metabolic processes. There is compelling evidence that amino acids themselves regulate protein synthesis, degradation and cell growth. Mammalian target of rapamycin complex 1 (mTORC1) plays a central role in cellular growth regulation. Amino acids potently activate mTORC1, however, the mechanism of amino acid signaling is largely unknown. Recent studies have identified Rag small GTPases as key components mediating amino acid signals to mTORC1 activation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acids / metabolism*
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Animals
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Humans
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Mechanistic Target of Rapamycin Complex 1
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Monomeric GTP-Binding Proteins / metabolism*
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Multiprotein Complexes
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Phosphatidylinositol 3-Kinases / metabolism*
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Protein Serine-Threonine Kinases / metabolism*
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Proteins
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Signal Transduction
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TOR Serine-Threonine Kinases
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Transcription Factors / metabolism*
Substances
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Amino Acids
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Multiprotein Complexes
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Proteins
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Transcription Factors
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Mechanistic Target of Rapamycin Complex 1
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Protein Serine-Threonine Kinases
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TOR Serine-Threonine Kinases
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Monomeric GTP-Binding Proteins