Abstract
We report the first autopsied case of paraneoplastic necrotizing myelopathy associated with esophageal cancer in the literature. The patient had acute flaccid paraplegia and urinary retention, and had a good recovery of strength of both legs in response to corticosteroids. MRI showed a characteristic lesion with post-gadolinium enhancement of the cervical to mid-thoracic spinal cord at the onset, which has never been reported. Taken together, these results suggest that there is an underlying autoimmune mechanism in paraneoplastic necrotizing myelopathy.
MeSH terms
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Aged
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Carcinoma, Squamous Cell / complications*
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / pathology
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Cervical Vertebrae
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Diagnosis, Differential
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Esophageal Neoplasms / complications*
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Esophageal Neoplasms / diagnosis
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Esophageal Neoplasms / pathology
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Esophagus / pathology
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Female
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Humans
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Magnetic Resonance Imaging
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Necrosis
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Paraneoplastic Syndromes, Nervous System / complications*
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Paraneoplastic Syndromes, Nervous System / diagnosis
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Paraneoplastic Syndromes, Nervous System / pathology
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Spinal Cord / pathology
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Spinal Cord Diseases / complications*
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Spinal Cord Diseases / diagnosis
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Spinal Cord Diseases / pathology
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Thoracic Vertebrae