Abstract
Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Child
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China
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Drug Resistance, Bacterial / genetics*
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Humans
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Macrolides / pharmacology*
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Microbial Sensitivity Tests
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Mycoplasma pneumoniae / drug effects*
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Mycoplasma pneumoniae / genetics
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Mycoplasma pneumoniae / isolation & purification
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Pneumonia, Mycoplasma / microbiology
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Point Mutation
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RNA, Ribosomal, 23S / genetics*
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Respiratory Tract Infections / microbiology
Substances
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Anti-Bacterial Agents
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Macrolides
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RNA, Ribosomal, 23S