Abstract
We studied a large panel of monoclonal antibodies reactive on routinely processed paraffin-embedded tissue to determine their sensitivity and specificity in the diagnosis of 35 primary cutaneous large cell lymphomas of B- (n = 14) and T-cell origin (n = 21). The findings show that differentiation between clinically relevant subgroups can be obtained by a small panel of antibodies including L26, MB2, LN1, MT1, UCHL1, and Ber-H2. Pitfalls in the use of the reagents are discussed.
MeSH terms
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Antibodies, Monoclonal*
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Biomarkers, Tumor / analysis*
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Diagnosis, Differential
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Humans
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Immunohistochemistry
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Lymphoma, B-Cell / diagnosis
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Lymphoma, B-Cell / immunology
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Lymphoma, Large B-Cell, Diffuse / diagnosis*
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Lymphoma, Large B-Cell, Diffuse / immunology
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Lymphoma, T-Cell, Cutaneous / diagnosis
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Lymphoma, T-Cell, Cutaneous / immunology
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Paraffin Embedding
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Phenotype
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Sensitivity and Specificity
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Skin / immunology
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Skin Neoplasms / diagnosis*
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Skin Neoplasms / immunology
Substances
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Antibodies, Monoclonal
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Biomarkers, Tumor