Abstract
A series of diphenyl ethers was prepared and evaluated for androgen receptor antagonist activity in human androgen receptor binding and cellular functional assays. Analogs with potent in vitro activities were evaluated for topical in vivo efficacy in the Golden Syrian Hamster ear model. Several compounds showed reduction in wax esters in this validated animal model.
MeSH terms
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Administration, Topical
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Androgen Antagonists / administration & dosage*
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Androgen Antagonists / chemistry*
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Androgen Receptor Antagonists*
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Animals
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Cell Line, Tumor
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Cricetinae
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Humans
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Male
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Mesocricetus
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Phenyl Ethers / administration & dosage*
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Phenyl Ethers / chemical synthesis*
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Receptors, Androgen / chemistry
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Reproducibility of Results
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Sebum / drug effects*
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Sebum / metabolism*
Substances
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Androgen Antagonists
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Androgen Receptor Antagonists
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Phenyl Ethers
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Receptors, Androgen