Harness the power: new insights into the inhibition of YAP/Yorkie

Dev Cell. 2009 Mar;16(3):321-2. doi: 10.1016/j.devcel.2009.02.015.

Abstract

YAP/Yorkie (Yki) is a transcriptional coactivator that controls organ size; dysregulation causes tumorigenesis by stimulating cell proliferation and inhibiting apoptosis. The Hippo pathway restrains YAP/Yki activity, but it remains unclear how cellular regulation at the plasma membrane influences the Hippo-YAP/Yki pathway. Two papers in this issue on Developmental Cell, by Badouel et al. and Nishioka et al., address this question.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / antagonists & inhibitors*
  • Drosophila
  • Drosophila Proteins / antagonists & inhibitors*
  • Drosophila Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mammals
  • Models, Biological
  • Nuclear Proteins / antagonists & inhibitors*
  • Protein Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • Trans-Activators / antagonists & inhibitors*
  • YAP-Signaling Proteins

Substances

  • Apoptosis Regulatory Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • Trans-Activators
  • YAP-Signaling Proteins
  • Yki protein, Drosophila
  • Protein Serine-Threonine Kinases
  • hpo protein, Drosophila