Abstract
Biliary stasis can occur in many different diseases. Pruritus, metabolic bone disease, deficiencies of fat-soluble vitamins, steatorrhea, hyperlipidemia and fatigue represent the major extra-hepatic manifestations of cholestatic liver disease that considerably affect the patient's quality of life. The present article reviews pathogenetic and clinical aspects of and current therapeutic approaches to extra-hepatic manifestations of cholestatic liver disease.
MeSH terms
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Anion Exchange Resins / therapeutic use
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Calcium / therapeutic use
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Cholestasis, Extrahepatic / complications*
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Cholestasis, Extrahepatic / metabolism
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Cholestasis, Extrahepatic / therapy
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Drug Therapy, Combination
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Fatigue / etiology
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Hemoperfusion
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Humans
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Hypercholesterolemia / etiology
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Hyperlipidemias / etiology
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Liver Transplantation
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Malabsorption Syndromes / etiology
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Narcotic Antagonists / therapeutic use
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Osteoporosis / etiology
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Plasmapheresis
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Pruritus / etiology
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Quality of Life
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Steatorrhea / etiology
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Treatment Outcome
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Ultraviolet Therapy
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Vitamin D / therapeutic use
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Vitamins / metabolism
Substances
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Anion Exchange Resins
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Narcotic Antagonists
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Vitamins
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Vitamin D
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Calcium