Abstract
Form and function: The natural product myxopyronin A provides the key to understanding the inhibition of bacterial RNA polymerase and should spark new ideas for the design of new antibiotics against tuberculosis and other infectious diseases.
MeSH terms
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Antibiotics, Antitubercular / chemistry*
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Antibiotics, Antitubercular / pharmacology
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DNA-Directed RNA Polymerases / antagonists & inhibitors*
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Drug Design
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Lactones / chemistry*
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Lactones / pharmacology
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / enzymology
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Mycobacterium tuberculosis / genetics
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Transcription, Genetic / drug effects*
Substances
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Antibiotics, Antitubercular
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Enzyme Inhibitors
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Lactones
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myxopyronin A
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DNA-Directed RNA Polymerases