Abstract
Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated from Okinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agelas / chemistry*
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Aspergillus niger / drug effects
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Escherichia coli / drug effects
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Imidazoles / chemistry
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Imidazoles / isolation & purification*
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Imidazoles / pharmacology
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
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Staphylococcus aureus / drug effects
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Trichophyton / drug effects
Substances
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Alkaloids
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Imidazoles
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Pyrroles
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nagelamide Q
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nagelamide R