The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus

Clin Chim Acta. 2009 May;403(1-2):223-5. doi: 10.1016/j.cca.2009.03.016. Epub 2009 Mar 17.

Abstract

Background: Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE).

Methods: One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay.

Results: In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455).

Conclusions: The IL-16 gene polymorphisms may be associated with the risk of SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Interleukin-16 / genetics*
  • Lupus Erythematosus, Systemic / genetics*
  • Male
  • Polymorphism, Genetic*

Substances

  • Interleukin-16