Abstract
In Japan, typical hairy cell leukemia (HCL) is rare, and HCL-Japanese variant (HCL-JV) is more common. Hairy B-cell lymphoproliferative disorder (HBLD) is another unusual disorder of polyclonal B-lymphocytosis of hairy cell appearance. In the present study, we analyzed the clinical features of 3 patients with HCL, 3 with HCL-JV, and 3 with HBLD. All HBLD patients had the DRB1*04 allele. As compared with other B-cell lymphoproliferative disorders, CD27 expression on B cells was significantly lower in all patients, ranging from 0.3% to 23.4%. Our results suggest that low CD27 expression may be a distinct feature of these HCL-related disorders.
MeSH terms
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Aged
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Aged, 80 and over
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Biomarkers / metabolism
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Case-Control Studies
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Female
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HLA-DR Antigens / metabolism
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HLA-DRB1 Chains
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Humans
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Immunoglobulin Heavy Chains / metabolism
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Japan
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Leukemia, Hairy Cell / ethnology*
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Leukemia, Hairy Cell / metabolism*
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
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Lymphoma / metabolism
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Lymphoma, Follicular / metabolism
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Lymphoproliferative Disorders / metabolism*
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Male
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Middle Aged
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism*
Substances
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Biomarkers
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HLA-DR Antigens
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HLA-DRB1 Chains
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HLA-DRB1*04 antigen
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Immunoglobulin Heavy Chains
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Tumor Necrosis Factor Receptor Superfamily, Member 7