Recurrence of cryptococcal meningitis in HIV-infected patients following immune reconstitution

Int J STD AIDS. 2009 Apr;20(4):274-5. doi: 10.1258/ijsa.2008.008312.

Abstract

Two HIV-infected patients had recurrent cryptococcal meningitis (CM) despite treatment with fluconazole and immune reconstitution with combination antiretroviral therapy (CART). Following treatment of CM with fluconazole, lumbar puncture should be performed either after completion of induction treatment for CM or before starting CART, in order to confirm cerebrospinal fluid sterility.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / immunology
  • Adolescent
  • Adult
  • Amphotericin B / therapeutic use
  • Anti-HIV Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • Fatal Outcome
  • Fluconazole / therapeutic use
  • HIV Seropositivity / complications
  • HIV Seropositivity / drug therapy*
  • HIV-1*
  • Humans
  • Male
  • Meningitis, Cryptococcal / diagnosis*
  • Meningitis, Cryptococcal / drug therapy
  • Meningitis, Cryptococcal / immunology
  • Recurrence

Substances

  • Anti-HIV Agents
  • Antifungal Agents
  • Amphotericin B
  • Fluconazole