Structural abnormalities of the female genital tract, whether congenital or acquired could result in infertility or reproductive failure. This study retrospectively analysed the structural abnormalities found in patients who had hysterosalpingography in the Lagos State University Teaching Hospital (LASUTH), Ikeja. A descriptive analysis of structural abnormality of the uterine cavity, fallopian tube and the cervical canal in two hundred and fifty patients, who were referred from the gynaecology clinic to the Radiology Department of LASUTH, from January to December 2005, is presented. The commonest abnormality seen was tubal blockage (56.8%) whether unilateral or bilateral. Filling defects (16%) were seen within or outside the uterus, causing irregularity of its wall. These could be due to fibroids, endometrial polyps or fibrous tissue causing adhesions. Cervical canal (19.8%) abnormalities were also noted. Only two cases of congenital anomalies were seen. We found that hysterosalpingography is a relatively cheap and easy mode of diagnosing structural anomalies of the genital tract such as fibroids and tubal pathologies.