Assessment of the amino acid substitution in HLA-B*5719 for allorecognition

Tissue Antigens. 2009 Apr;73(4):376-8. doi: 10.1111/j.1399-0039.2009.01227.x.

Abstract

The novel allele human leukocyte antigen (HLA)-B*5719 differs from HLA-B*5701 by a synonymous nucleotide exchange at position 539 in exon 3 (C-->T), replacing Leucine by Arginine at amino acid position 156 in the alpha2 domain.

MeSH terms

  • Amino Acid Substitution
  • Arginine / genetics
  • Base Sequence
  • Genetic Variation
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Histocompatibility Testing
  • Humans
  • Isoantigens / genetics
  • Leucine / genetics
  • Molecular Sequence Data

Substances

  • HLA-B Antigens
  • HLA-B*57:19 antigen
  • Isoantigens
  • Arginine
  • Leucine

Associated data

  • GENBANK/FM207448