Abstract
Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients. Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma). Primary glioblastomas develop in older patients while secondary glioblastomas develop in younger patients and contain TP53 mutations as the earliest detectable change. We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophysiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.
MeSH terms
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Adult
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / metabolism
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Cerebellar Neoplasms / genetics
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Cerebellar Neoplasms / pathology*
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Cerebellar Neoplasms / physiopathology
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Cerebellum / diagnostic imaging
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Cerebellum / pathology
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Cerebellum / surgery
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Fatal Outcome
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Female
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Fourth Ventricle / pathology
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Fourth Ventricle / surgery
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Genetic Predisposition to Disease / genetics*
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Glioblastoma / genetics
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Glioblastoma / pathology*
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Glioblastoma / physiopathology
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Headache / etiology
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Humans
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Hydrocephalus / etiology
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Intracranial Hypertension / etiology
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Magnetic Resonance Imaging
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Mutation / genetics*
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Neoplasm Recurrence, Local
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Neurosurgical Procedures / methods
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Reoperation
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Tomography, X-Ray Computed
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Tumor Suppressor Protein p53 / genetics*
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Vomiting / etiology
Substances
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Biomarkers, Tumor
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Tumor Suppressor Protein p53