Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: report of a case

Surg Today. 2009;39(4):335-9. doi: 10.1007/s00595-008-3863-y. Epub 2009 Mar 25.

Abstract

Multicentricity of gastrointestinal stromal tumors (GISTs) has been described only in patients with neurofibromatosis type 1 (NF1) or within the small intestine, and different pathogenetic mechanisms are involved. We report a case of synchronous sporadic gastric and jejunal GISTs, which were resected laparoscopically in a 67-year-old man. Immunohistochemical analysis revealed that both lesions were KIT (CD117)-positive, but that the gastric lesion was CD34-positive, whereas the jejunal one was Vimentin-, S-100-, and SMA-positive. Molecular analysis of mutations in KIT exons 9, 11, 13, and 17, and in PDGFRA exons 12 and 18 revealed the presence of a gastric sporadic GIST with a KIT mutation of the exon 11 and a jejunal sporadic GIST without KIT or PDGFRA mutations. To our knowledge, this is the first report of laparoscopically resected synchronous sporadic gastric and jejunal GISTs.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Exons
  • Gastrointestinal Stromal Tumors / diagnosis
  • Gastrointestinal Stromal Tumors / surgery*
  • Humans
  • Immunohistochemistry
  • Jejunal Neoplasms / diagnosis
  • Jejunal Neoplasms / surgery*
  • Laparoscopy
  • Male
  • Mutation
  • Neoplasms, Multiple Primary / diagnosis
  • Neoplasms, Multiple Primary / surgery
  • Proto-Oncogene Proteins c-kit / genetics
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / surgery*

Substances

  • Proto-Oncogene Proteins c-kit