Functional analysis of the promoter of the gene encoding the acidic ribosomal protein L45 in yeast

Biochim Biophys Acta. 1991 Oct 8;1090(2):204-10. doi: 10.1016/0167-4781(91)90102-r.

Abstract

The gene encoding the acidic ribosomal protein L45 in yeast is expressed coordinately with other rp-genes. The promoter region of this gene harbours binding sites for CP1 and ABF1. We demonstrate that the CP1-site is not involved in the transcription activation of the L45-gene. Rather, the ABF1-site, through deviating from the consensus sequence (RTARY3N3ACG), appears to be essential for efficient transcription. Replacement of this site by a consensus RAP1-binding site (an RPG box) did not alter the transcriptional yield of the L45-gene. An additional transcription activating region is present downstream of the ABF1-site. The relevant nucleotide sequence, which is repeated in the L45-gene promoter, gives rise to complex formation with a yeast protein extract in a bandshift assay. The results indicate that the L45-gene promoter has a complex architecture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Binding Sites
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Genes, Fungal*
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • Ribosomal Protein L3
  • Ribosomal Proteins / genetics*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors*
  • Transcription, Genetic

Substances

  • ABF1 protein, S cerevisiae
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • CBF1 protein, S cerevisiae
  • DNA-Binding Proteins
  • Fungal Proteins
  • Ribosomal Protein L3
  • Ribosomal Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors