Abstract
Forty-eight Fusarium isolates morphologically identified as belonging to seven species of clinical interest (i.e., Fusarium chlamydosporum, Fusarium dimerum, Fusarium incarnatum, Fusarium napiforme, Fusarium nygamai, Fusarium proliferatum, and Fusarium sacchari) were characterized molecularly by the analysis of the sequences of the TUB region of the beta-tubulin gene. F. chlamydosporum and F. dimerum were the most genetically heterogeneous species. A high degree of correlation between the morphological and molecular identification was shown among the isolates studied. A table with the key morphological features for the identification of these Fusarium species is provided. The antifungal susceptibilities of the Fusarium isolates to 11 antifungal drugs were tested; terbinafine was the most active drug against all the species tested with the exception of F. incarnatum, for which amphotericin B was the most active.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology
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Antifungal Agents / pharmacology
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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Fungal Proteins / genetics
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Fusarium / cytology
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Fusarium / drug effects*
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Fusarium / genetics*
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Fusarium / isolation & purification
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mycoses / microbiology*
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Naphthalenes / pharmacology
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Polymorphism, Genetic
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Sequence Analysis, DNA
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Terbinafine
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Tubulin / genetics
Substances
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Antifungal Agents
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DNA, Fungal
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Fungal Proteins
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Naphthalenes
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Tubulin
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Amphotericin B
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Terbinafine
Associated data
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GENBANK/FM878605
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GENBANK/FM878606
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GENBANK/FM878607
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GENBANK/FM878608
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GENBANK/FM878609
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GENBANK/FM878610
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GENBANK/FM878611
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GENBANK/FM878612
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GENBANK/FM878613
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GENBANK/FM878614
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GENBANK/FM878615
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GENBANK/FM878616
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GENBANK/FM878617
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GENBANK/FM878618
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GENBANK/FM878619
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GENBANK/FM878620
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GENBANK/FM878621
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GENBANK/FM878622
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GENBANK/FM878623
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GENBANK/FM878624
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GENBANK/FM878625
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GENBANK/FM878626
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GENBANK/FM878627
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GENBANK/FM878628
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GENBANK/FM878629
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GENBANK/FM878630
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GENBANK/FM878631
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GENBANK/FM878632
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GENBANK/FM878633
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GENBANK/FM878634
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GENBANK/FM878635
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GENBANK/FM878926
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GENBANK/FM878927
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GENBANK/FM878928
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GENBANK/FM878929
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GENBANK/FM878930
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GENBANK/FM878931
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GENBANK/FM878932
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GENBANK/FM878933
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GENBANK/FM878934
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GENBANK/FM878935
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GENBANK/FM878936
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GENBANK/FM878937
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GENBANK/FM878938
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GENBANK/FM878939
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GENBANK/FM878940
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GENBANK/FM878941
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GENBANK/FM878942