Fluorescent assay of DNA hybridization with label-free molecular switch: reducing background-signal and improving specificity by using carbon nanotubes

Chem Commun (Camb). 2009 Feb 14:(6):665-7. doi: 10.1039/b819526a. Epub 2009 Jan 7.

Abstract

Using classic DNA-intercalating dye and carbon nanotubes, a simple, but efficient, method for fluorescent detection of DNA hybridization has been developed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Pair Mismatch
  • Base Sequence
  • DNA / analysis
  • DNA / chemistry*
  • DNA / genetics
  • Fluorescent Dyes / chemistry*
  • Nanotubes, Carbon / chemistry*
  • Nucleic Acid Hybridization
  • Sensitivity and Specificity
  • Staining and Labeling

Substances

  • Fluorescent Dyes
  • Nanotubes, Carbon
  • DNA