Abstract
In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution / genetics
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Dengue Virus / classification*
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Dengue Virus / genetics*
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Dengue Virus / isolation & purification
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Epitopes / genetics
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Genetic Variation*
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Genotype
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Humans
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Latin America
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Models, Molecular
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Molecular Sequence Data
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Phylogeny
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Protein Structure, Tertiary
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RNA, Viral / genetics*
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology
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Viral Envelope Proteins / genetics
Substances
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E protein, Dengue virus type 3
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Epitopes
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RNA, Viral
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Viral Envelope Proteins
Associated data
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GENBANK/FM246466
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GENBANK/FM246467
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GENBANK/FM246468
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GENBANK/FM246469
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GENBANK/FM246470
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GENBANK/FM246471
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GENBANK/FM246473