It takes two binding sites for calcineurin and NFAT to tango

Jun O Liu; Benjamin A Nacev; Jing Xu; Shridhar Bhat

doi:10.1016/j.molcel.2009.03.005

It takes two binding sites for calcineurin and NFAT to tango

Mol Cell. 2009 Mar 27;33(6):676-8. doi: 10.1016/j.molcel.2009.03.005.

Authors

Jun O Liu¹, Benjamin A Nacev, Jing Xu, Shridhar Bhat

Affiliation

¹ Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. [email protected]

PMID: 19328062
DOI: 10.1016/j.molcel.2009.03.005

Abstract

In a recent issue of Molecular Cell, Rodríguez et al. (2009) identified the NFAT LxVP motif binding site as the same composite surface formed by the two calcineurin subunits that is recognized by the cyclophilin-CsA and FKBP-FK506 complexes.

Publication types

Comment

MeSH terms

Animals
Binding Sites
Calcineurin / metabolism*
Humans
NFATC Transcription Factors / metabolism*

Substances

NFATC Transcription Factors
Calcineurin