Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis

André Luís Branco de Barros; Valbert Nascimento Cardoso; Luciene das Graças Mota; Elaine Amaral Leite; Mônica Cristina de Oliveira; Ricardo José Alves

doi:10.1016/j.bmcl.2009.03.059

Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis

Bioorg Med Chem Lett. 2009 May 1;19(9):2497-9. doi: 10.1016/j.bmcl.2009.03.059. Epub 2009 Mar 18.

Authors

André Luís Branco de Barros¹, Valbert Nascimento Cardoso, Luciene das Graças Mota, Elaine Amaral Leite, Mônica Cristina de Oliveira, Ricardo José Alves

Affiliation

¹ Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.

PMID: 19332368
DOI: 10.1016/j.bmcl.2009.03.059

Abstract

A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, d-glucose-MAG(3) is a potential agent for tumor diagnosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemistry, Pharmaceutical / methods*
Drug Design
Glucose / chemistry*
Mice
Models, Chemical
Neoplasm Transplantation
Neoplasms / diagnosis*
Neoplasms / metabolism
Neoplasms, Experimental / diagnosis
Radiopharmaceuticals*
Solvents / chemistry
Technetium / chemistry*
Technetium Tc 99m Mertiatide*
Tissue Distribution

Substances

Radiopharmaceuticals
Solvents
Technetium Tc 99m Mertiatide
Technetium
Glucose