Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: report of an autopsy case

Cédric Annweiler; Marc Paccalin; Gilles Berrut; Caroline Hommet; Christian Lavigne; Jean-Paul Saint-André; Olivier Beauchet

doi:10.2147/vhrm.s3818

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: report of an autopsy case

Vasc Health Risk Manag. 2008;4(6):1471-4. doi: 10.2147/vhrm.s3818.

Authors

Cédric Annweiler¹, Marc Paccalin, Gilles Berrut, Caroline Hommet, Christian Lavigne, Jean-Paul Saint-André, Olivier Beauchet

Affiliation

¹ Department of Geriatrics and Internal Medicine, Angers University Hospital, Angers Cedex 9, France.

Abstract

The association of angiitis of central nervous system (ACNS) with cerebral amyloid angiopathy (CAA) suggests a physiopathological relationship between these two affections. Few cases are reported in patients with Alzheimer's disease (AD). We describe here a clinicopathological case associating ACNS, CAA, and AD. We discuss the aetiology of ACNS and its relationship with cerebral deposition of beta A4 amyloid protein (betaA4).

Keywords: Alzheimer’s disease; cerebral angiopathy.

Publication types

Case Reports

MeSH terms

Aged
Alzheimer Disease / metabolism
Alzheimer Disease / pathology*
Alzheimer Disease / therapy
Amyloid beta-Peptides / analysis
Autopsy
Brain / pathology*
Brain Chemistry
Cerebral Amyloid Angiopathy / metabolism
Cerebral Amyloid Angiopathy / pathology*
Cerebral Amyloid Angiopathy / therapy
Fatal Outcome
Female
Humans
Treatment Outcome
Vasculitis, Central Nervous System / metabolism
Vasculitis, Central Nervous System / pathology*
Vasculitis, Central Nervous System / therapy

Substances

Amyloid beta-Peptides