Abstract
Neuropsychological deficits are among the negative side effects of adjuvant chemotherapy for breast cancer. We compared the effects of two types of neuropsychological interventions against a control group with no specific training in a total of 96 female in-patients undergoing oncological rehabilitation. Most results of a comprehensive neuropsychological test battery improved significantly during the patients' oncological rehabilitation in all three groups; we identified no specific intervention effects. We observed little overall correlation between the neuropsychological test results and the patients' own appraisals of their mental capacity. Clinically relevant neuropsychological deficits were still evident 6 months later in a small subgroup of patients.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Attention / drug effects
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / psychology
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Breast Neoplasms / surgery
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Chemotherapy, Adjuvant
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Cognition Disorders / chemically induced*
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Cognition Disorders / psychology
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Cognition Disorders / rehabilitation*
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Computer-Assisted Instruction*
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Female
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Germany
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Humans
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Memory Disorders / chemically induced
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Memory Disorders / psychology
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Memory Disorders / rehabilitation
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Memory, Short-Term / drug effects
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Middle Aged
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Neuropsychological Tests / statistics & numerical data*
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Occupational Therapy*
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Practice, Psychological*
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Psychometrics
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Quality of Life / psychology
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Reaction Time / drug effects
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Software