Abstract
Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.
MeSH terms
-
Adolescent
-
Adult
-
Animals
-
Antibodies, Protozoan / blood*
-
Cell Proliferation
-
Cells, Cultured
-
Child, Preschool
-
Humans
-
Infant
-
Interferon-gamma / biosynthesis
-
Leishmania major / immunology*
-
Leishmaniasis, Cutaneous / immunology*
-
Leishmaniasis, Visceral / immunology*
-
Leukocytes, Mononuclear / immunology*
-
Mitogen-Activated Protein Kinase Kinases / immunology
-
Protein Disulfide-Isomerases / immunology
-
Protozoan Proteins / immunology
-
Virulence Factors / immunology*
-
Young Adult
Substances
-
Antibodies, Protozoan
-
Protozoan Proteins
-
Virulence Factors
-
Interferon-gamma
-
Mitogen-Activated Protein Kinase Kinases
-
Protein Disulfide-Isomerases