Abstract
Four novel oxylipins (1-4) were isolated from the n-butanol extract of the corms of Dracontium loretense. Their structures were assigned by 1D and 2D NMR analyses and electrospray ionization multistage ion trap mass spectrometry (ESI-ITMS(n)) data. Relative configurations were assigned on the basis of combined analysis of homonuclear and heteronuclear (2,3)J couplings, along with ROE data. Oxylipin 2 exhibited an immunostimulatory effect on human PBMC proliferation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / blood
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Adjuvants, Immunologic / chemistry
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Adjuvants, Immunologic / isolation & purification*
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Adjuvants, Immunologic / pharmacology
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Humans
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Leukocytes, Mononuclear / drug effects*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oxylipins / blood
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Oxylipins / chemistry
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Oxylipins / immunology
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Oxylipins / isolation & purification*
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Peru
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Plants, Medicinal / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Adjuvants, Immunologic
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Oxylipins