Psoriasis--a systemic inflammatory disorder: clinic, pathogenesis and therapeutic perspectives

J Dtsch Dermatol Ges. 2009 Nov;7(11):946-52. doi: 10.1111/j.1610-0387.2009.07083.x.
[Article in English, German]

Abstract

Psoriasis has seen a dramatic change in its perception by dermatologists as well as other medical specialties. Its well-recognized association with several other diseases makes a complete switch in its management necessary. This review summarizes current epidemiological data on the comorbidities of psoriasis. Subsequently, the evidence for insulin resistance as a cause for endothelial cell dysfunction with its relevant pathogenetic link to the development of cardiovascular comorbidity is discussed. Based on these novel insights, we propose a possible state-of-the-art approach towards comprehensive psoriasis management.

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Inflammation / complications
  • Inflammation / diagnosis*
  • Inflammation / drug therapy*
  • Psoriasis / complications
  • Psoriasis / diagnosis*
  • Psoriasis / drug therapy*

Substances

  • Anti-Inflammatory Agents
  • Dermatologic Agents