Abstract
Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics*
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Cholera / epidemiology
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Cholera / microbiology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Disease Outbreaks
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Gene Expression Regulation
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Molecular Sequence Data
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Phylogeny
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Polymorphism, Genetic
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Quorum Sensing*
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Selection, Genetic*
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Sequence Analysis, DNA
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Vibrio cholerae O1 / genetics
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Vibrio cholerae O1 / physiology*
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Vibrio cholerae O139 / genetics
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Vibrio cholerae O139 / physiology*
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Vibrio cholerae non-O1 / genetics
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Vibrio cholerae non-O1 / physiology*
Substances
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Bacterial Proteins
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DNA, Bacterial
Associated data
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GENBANK/EU523702
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GENBANK/EU523703
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GENBANK/EU523704
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GENBANK/EU523705
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GENBANK/EU523706
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GENBANK/EU523707
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GENBANK/EU523708
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GENBANK/EU523709
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GENBANK/EU523710
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GENBANK/EU523711
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GENBANK/EU523712
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GENBANK/EU523713
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GENBANK/EU523714
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GENBANK/EU523715
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GENBANK/EU523716
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GENBANK/EU523717
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GENBANK/EU523718
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GENBANK/EU523719
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GENBANK/EU523720
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GENBANK/EU523721
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GENBANK/EU523722
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GENBANK/EU523723
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GENBANK/EU523724
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GENBANK/EU523725
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GENBANK/EU523726