Objectives: To assess intraobserver and interobserver variability in cardiac computed tomographic measurements of global biventricular function, left ventricular (LV) regional wall motion, systolic wall thickening, and first pass perfusion in 3 patient cohorts at very low, low to intermediate, and intermediate to high cardiac risk.
Methods: One hundred thirty-three patients underwent 64-channel cardiac computed tomography. Images were analyzed by 2 experienced, blinded observers. Intraobserver and interobserver agreements were calculated for each cohort and were combined for patients with structurally normal hearts.
Results: Intraobserver and interobserver agreements were good for all global and regional LV parameters with narrow levels of agreement. Right ventricular ejection fraction agreement was also good, but other right ventricular parameters showed wide levels of agreement.
Conclusions: Biventricular ejection fraction, LV regional wall motion, and systolic wall thickening, volume, and mass show good reproducibility for use in standard clinical practice. Right ventricular volumetric and mass data in patients with congenital heart disease should be interpreted with caution.